March 11, 2026 at 9:43 am EDT

My name is Dr. Rachel Simmons. I'm a licensed naturopathic doctor.

I've been in practice for 16 years. Over the last 18 months I've watched a new kind of patient walk into my clinic, and I couldn't figure out why nothing was working for them.

This is what I finally learned.

They were 40 to 55. Mostly women. Every single one had been on Ozempic, Wegovy, Mounjaro, or Zepbound for somewhere between 6 and 18 months.

They'd come off the shot and were watching their numbers climb back up.

A1c's that had dropped to 5.2 on the drug were now 5.8, 5.9, sometimes 6.1.

Fasting glucose that hit 86 on the pen was reading 109, 117, 124 in the morning.

The food noise was back. The cravings were back.

These weren't lazy patients. They had cgms taped to their arms. They were tracking. They were trying.

And the standard supplement protocol I'd used for two decades was barely moving their numbers.

One patient stood out.

47 years old. Spent $9,400 on Mounjaro over 14 months. Came off in March.

By June her fasting glucose was 109. Her a1c was 5.9 — higher than the day she first started the drug.

She showed me a pile of supplement bottles.

Thorne berberine — made her throw up in her office bathroom. Glucose Goddess Anti-Spike powder. Inositol. A "Nature's Ozempic" gummy from tiktok.

Over $200 in supplements doing nothing.

I'd seen the same paper bag from 30 different patients in the last year.

That's when I started asking why.

I spent two months going back through the bioavailability literature on every botanical I'd been prescribing.

What I found changed how I practice.

Berberine in standard capsule form has under 5% bioavailability.

Under five percent.

That means 95% of what's swallowed never reaches the bloodstream. It hits stomach acid, gets denatured, passes through the liver's first-pass metabolism, and exits the body.

Cinnamon cassia. Bitter melon. Turmeric. The same problem.

These are plant compounds. Capsules were designed for synthetic pharmaceuticals — molecules engineered to survive stomach acid. Botanicals weren't built that way.

The supplement industry stuffs them into capsules anyway because it's cheaper to manufacture.

But the actual mechanism was failing at the delivery stage.

It wasn't that my patients' bodies were broken from the GLP-1.

It was that 95% of what they were swallowing was being destroyed before it could do anything.

This isn't new information.

Naturopathic doctors have been prescribing 1:5 liquid herbal extracts for over a hundred years. It's the format integrative medicine has always used for plant compounds.

Concentrated. Preserved in glycerin. Absorbed in minutes — not 90.

No capsule to dissolve. No stomach acid bottleneck. No first-pass metabolism wall.

This is how botanicals were meant to be delivered. It just got buried under a supplement industry that makes more margin selling 60 capsules in a bottle than a 2-ounce liquid.

Four months ago a colleague at a functional medicine clinic in Cleveland mentioned a liquid formula she'd been using with her own post-GLP-1 patients.

It's called catalyst°.

Three things stood out.

First: the delivery. Every botanical is a 1:5 liquid extract. One full dropper taken straight or mixed into any beverage — absorbed in minutes.

Second: the formulation. Cinnamon cassia bark at 500 mg for insulin sensitivity. Licorice root at 174 mg for the cortisol-glucose axis. Turmeric, coriander seed, and bitter melon for the AMPK pathway. Japanese knotweed for resveratrol.

Third: the dosing. Real clinically-studied amounts, not the sub-therapeutic "fairy dust" doses on most retail bottles.

I started recommending it to Sarah first.

I started recommending it to Sarah first.

Sarah came back four weeks later.

Her fasting glucose that morning was 94.

Her cgm post-meal spikes were returning to baseline within 90 minutes instead of staying elevated for three hours. The 9pm pantry trips had stopped within a week.

She wasn't the only one.

Of the 23 post-GLP-1 patients I've put on catalyst° in the last four months, 19 have seen their fasting glucose return to a normal range within 6 to 8 weeks.

I've never had a supplement protocol produce results that consistent in this specific population.

Too many of you are walking into clinics like mine after spending hundreds of dollars on bottles that were never going to work.

If you're 3, 6, 9 months off your shot and your numbers are climbing — this isn't your fault.

It's not your willpower. It's not your body being broken from the drug.

It's that the version of the supplements you've been buying was destroyed before it could reach the cells that needed it.

Capsules were the wrong delivery mechanism. They always were.

A single bottle of catalyst° is $29.99. Most of my patients order the Buy 2, Get 1 Free bundle at $59.99 — the runway most people need to see their numbers fully stabilize.

Free shipping on subscription. 365-day money-back guarantee. If your morning numbers don't move, mail the bottles back for a full refund.

Inventory has been tight since the brand was mentioned on a podcast in my space.

Keep buying capsules that dump 95% of the active ingredient into your toilet. Keep watching your morning number climb.

Or change the delivery.

I'm a naturopathic doctor who spent 16 years prescribing the wrong format of the right ingredients.

I won't make that mistake again. I'm writing this so you don't have to.